Structure of PDB 7ndm Chain A

Receptor sequence
>7ndmA (length=215) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TESLDLEFESAYRGRPPWSIGEPQPELAALIVQGKFRGDVLDVGCGEAAI
SLALAERGHTTVGLDLSPAAVELARHEAAKRGLANASFEVADASSFTGYD
GRFDTIVDSTLFHSMPVESREGYLQSIVRAAAPGASYFVLVFDRAAIPEG
PINAVTEDELRAAVSKYWIIDEIKPARLYARFPAGFAGMPALLDIREEPN
GLQSIGGWLLSAHLG
3D structure
PDB7ndm Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.374: 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F11 Y15 W30 G56 C57 G58 D77 L78 D104 A105 S121 T122 L123 S126 F8 Y12 W18 G44 C45 G46 D65 L66 D92 A93 S109 T110 L111 S114
BS02 U8N A P29 W30 F154 F194 P17 W18 F142 F182
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0001666 response to hypoxia
GO:0009751 response to salicylic acid
GO:0010106 cellular response to iron ion starvation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7ndm, PDBe:7ndm, PDBj:7ndm
PDBsum7ndm
PubMed34506908
UniProtP9WKL5|HTM_MYCTU 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase (Gene Name=htm)

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