Structure of PDB 7nd1 Chain A

Receptor sequence
>7nd1A (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
TWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKNTMTTK
ECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYP
3D structure
PDB7nd1 Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C67 H69 C87 C90 C52 H54 C72 C75
BS02 ZN A C51 C54 C72 C75 C36 C39 C57 C60
BS03 U9E A M62 L80 L94 S96 K97 L100 M47 L65 L79 S81 K82 L85
Gene Ontology
Cellular Component
GO:0000151 ubiquitin ligase complex

View graph for
Cellular Component
External links
PDB RCSB:7nd1, PDBe:7nd1, PDBj:7nd1
PDBsum7nd1
PubMed34155404
UniProtQ99496|RING2_HUMAN E3 ubiquitin-protein ligase RING2 (Gene Name=RNF2)

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