Structure of PDB 7nbq Chain A

Receptor sequence
>7nbqA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
SSGLVPRGSMESGFTSKDTYLSHFNPRDYLEKYYKFHSAESQILKHLLKN
LFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQEL
EKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVT
QSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLV
IMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSS
TMANNEGLFSLVARKL
3D structure
PDB7nbq Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.
ChainA
Resolution2.479 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y11 Y20 Y25 G63 S64 T67 Y69 D85 Y86 N90 D142 V143 T163 L164 C165 A169 Y20 Y29 Y34 G69 S70 T73 Y75 D91 Y92 N96 D148 V149 T169 L170 C171 A175 BindingDB: IC50=35300nM
BS02 U72 A Y20 Y24 L164 D167 A198 S201 Y204 S213 Y242 A247 Y29 Y33 L170 D173 A204 S207 Y210 S219 Y248 A253
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030760 pyridine N-methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:7nbq, PDBe:7nbq, PDBj:7nbq
PDBsum7nbq
PubMed33668468
UniProtP40261|NNMT_HUMAN Nicotinamide N-methyltransferase (Gene Name=NNMT)

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