Structure of PDB 7nb4 Chain A

Receptor sequence
>7nb4A (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
SEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDG
VQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLIS
FGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFF
H
3D structure
PDB7nb4 The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U6Q A H224 A227 F228 M231 V253 R263 T266 L267 F270 H55 A58 F59 M62 V84 R94 T97 L98 F101 BindingDB: Ki=510nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7nb4, PDBe:7nb4, PDBj:7nb4
PDBsum7nb4
PubMed34497901
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

[Back to BioLiP]