Structure of PDB 7n93 Chain A

Receptor sequence
>7n93A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKD
TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLER
EGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTD
FGLCKECGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGEN
RKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ
AHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPNQ
VFLGFEYVAPSV
3D structure
PDB7n93 Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
ChainA
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1SK A G98 K99 G100 K104 V105 A121 K123 L172 Y174 E222 N223 M225 D236 G12 K13 G14 K18 V19 A35 K37 L86 Y88 E136 N137 M139 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7n93, PDBe:7n93, PDBj:7n93
PDBsum7n93
PubMed34596404
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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