Structure of PDB 7n8s Chain A

Receptor sequence
>7n8sA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
HITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKI
KGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQ
EELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGAFNTPLSTLDRS
TRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTFFSAPHHTYSKIDH
IVGSKALLSKCKRTEIITNKLSDHSAIKLELR
3D structure
PDB7n8s Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease.
ChainA
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A N16 N19 K23 H45 K70 P197 N10 N13 K17 H39 K64 P191
BS02 dna A E43 K71 Y115 N118 N147 R155 T157 F193 H198 T200 S202 I204 E37 K65 Y109 N112 N141 R149 T151 F187 H192 T194 S196 I198
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:7n8s, PDBe:7n8s, PDBj:7n8s
PDBsum7n8s
PubMed34554261
UniProtO00370|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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