Structure of PDB 7n8l Chain A

Receptor sequence
>7n8lA (length=220) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TLVASVLPDLAYAELYSDPPGLTPLPEEAPLIARSVAKRRNEFITVRHCA
RIALDQLGVPPAPILKGDKGEPCWPDGMVGSLTHCAGYRGAVVGRRDAVR
SVGIDAEPHDVLPNGVLDAISLPAERADMPRTMPAALHWDRILFCAKEAT
YKAWFPLTKRWLGFEDAHITFETDSTGWTGRFVSRILIDGSTLSGPPLTT
LRGRWSVERGLVLTAIVLAG
3D structure
PDB7n8l In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.7: holo-[acyl-carrier-protein] synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A R48 R56 K75 K78 G79 E80 P81 L91 T92 H93 Y160 K161 F164 R39 R47 K66 K69 G70 E71 P72 L82 T83 H84 Y151 K152 F155
BS02 10I A E157 W170 L171 G172 F173 E148 W161 L162 G163 F164
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0008897 holo-[acyl-carrier-protein] synthase activity
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0046872 metal ion binding
Biological Process
GO:0009237 siderophore metabolic process
GO:0009239 enterobactin biosynthetic process
GO:0019290 siderophore biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0009366 enterobactin synthetase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7n8l, PDBe:7n8l, PDBj:7n8l
PDBsum7n8l
PubMed35044775
UniProtO33336|PPTT_MYCTU 4'-phosphopantetheinyl transferase PptT (Gene Name=pptT)

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