Structure of PDB 7n7m Chain A

Receptor sequence
>7n7mA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
SDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKEN
MPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDARFHTSYD
KRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGV
EIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFI
NEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAGEF
DPNIDVYGIKCHENSPRKEVYFMAIIDILTHVNPEQYSKRFLDFIGHIL
3D structure
PDB7n7m Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.149: 1-phosphatidylinositol-5-phosphate 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R78 A N124 F134 I143 T196 N198 V199 F200 I358 N91 F95 I104 T157 N159 V160 F161 I276
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0042803 protein homodimerization activity
GO:0052742 phosphatidylinositol kinase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0010506 regulation of autophagy
GO:0016310 phosphorylation
GO:0035855 megakaryocyte development
GO:0046488 phosphatidylinositol metabolic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0061909 autophagosome-lysosome fusion
GO:0090119 vesicle-mediated cholesterol transport
GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
GO:2000786 positive regulation of autophagosome assembly
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7n7m, PDBe:7n7m, PDBj:7n7m
PDBsum7n7m
PubMed34001596
UniProtP48426|PI42A_HUMAN Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (Gene Name=PIP4K2A)

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