Structure of PDB 7n74 Chain A
Receptor sequence
>7n74A (length=1036) Species:
9606
(Homo sapiens) [
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SVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLA
HAETLVIEIWQLFTVQVQTEVLRYYLFQGQRYIWIETQQAFYQVSLLDHG
RSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYY
GFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKL
SMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVN
ESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHV
LAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTI
YSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQ
GIFCIHPLRINLGGKLQLVCFNKTGTLTEDGLDVMGVVPLKGQAFLPLVP
EPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEDSAFG
TQVPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCN
PETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGD
LSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCG
MVAPQEHLIIVHATHPERGQPASLEFLPMESRSRHLALSGPTFGIIVKHF
PKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALK
AADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYM
ALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVL
GRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVA
APDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTNVPFLVALAL
LSSVLVGLVLVPGLLQGPLALRNITDTGFKLLLLGLVTLNFVGAFMLESV
LDQCLPACLRRLRPKRASKKRFKQLERELAEQPWPP
3D structure
PDB
7n74
Structural basis of polyamine transport by human ATP13A2 (PARK9).
Chain
A
Resolution
2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
7.6.2.-
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
ATP
A
N508 T510 M568 D569 F625 M632 K649 T745 G746 R848 K854 N876
N422 T424 M482 D483 F515 M522 K539 T635 G636 R716 K722 N744
BS02
Y01
A
I264 L268 R484 T968 V971
I178 L182 R398 T836 V839
BS03
Y01
A
T968 L1082
T836 L950
Gene Ontology
Molecular Function
GO:0000166
nucleotide binding
GO:0005215
transporter activity
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0008270
zinc ion binding
GO:0008289
lipid binding
GO:0015203
polyamine transmembrane transporter activity
GO:0015417
ABC-type polyamine transporter activity
GO:0015662
P-type ion transporter activity
GO:0016887
ATP hydrolysis activity
GO:0019829
ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0030145
manganese ion binding
GO:0046872
metal ion binding
GO:0070300
phosphatidic acid binding
GO:0080025
phosphatidylinositol-3,5-bisphosphate binding
GO:0140358
P-type transmembrane transporter activity
GO:1903135
cupric ion binding
Biological Process
GO:0006874
intracellular calcium ion homeostasis
GO:0006879
intracellular iron ion homeostasis
GO:0006882
intracellular zinc ion homeostasis
GO:0006914
autophagy
GO:0007041
lysosomal transport
GO:0010628
positive regulation of gene expression
GO:0010821
regulation of mitochondrion organization
GO:0016241
regulation of macroautophagy
GO:0016243
regulation of autophagosome size
GO:0030003
intracellular monoatomic cation homeostasis
GO:0033157
regulation of intracellular protein transport
GO:0034220
monoatomic ion transmembrane transport
GO:0034599
cellular response to oxidative stress
GO:0043523
regulation of neuron apoptotic process
GO:0046777
protein autophosphorylation
GO:0050714
positive regulation of protein secretion
GO:0052548
regulation of endopeptidase activity
GO:0055085
transmembrane transport
GO:0055088
lipid homeostasis
GO:0061462
protein localization to lysosome
GO:0061909
autophagosome-lysosome fusion
GO:0071287
cellular response to manganese ion
GO:0071294
cellular response to zinc ion
GO:0097734
extracellular exosome biogenesis
GO:0098655
monoatomic cation transmembrane transport
GO:1900180
regulation of protein localization to nucleus
GO:1902047
polyamine transmembrane transport
GO:1903146
regulation of autophagy of mitochondrion
GO:1903543
positive regulation of exosomal secretion
GO:1903710
spermine transmembrane transport
GO:1904714
regulation of chaperone-mediated autophagy
GO:1905037
autophagosome organization
GO:1905123
regulation of glucosylceramidase activity
GO:1905165
regulation of lysosomal protein catabolic process
GO:1905166
negative regulation of lysosomal protein catabolic process
GO:1990938
peptidyl-aspartic acid autophosphorylation
GO:2000152
regulation of ubiquitin-specific protease activity
Cellular Component
GO:0000421
autophagosome membrane
GO:0005764
lysosome
GO:0005765
lysosomal membrane
GO:0005768
endosome
GO:0005770
late endosome
GO:0005771
multivesicular body
GO:0005776
autophagosome
GO:0012506
vesicle membrane
GO:0016020
membrane
GO:0030133
transport vesicle
GO:0031902
late endosome membrane
GO:0031982
vesicle
GO:0032585
multivesicular body membrane
GO:0043005
neuron projection
GO:0043025
neuronal cell body
GO:0043202
lysosomal lumen
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:7n74
,
PDBe:7n74
,
PDBj:7n74
PDBsum
7n74
PubMed
34715013
UniProt
Q9NQ11
|AT132_HUMAN Polyamine-transporting ATPase 13A2 (Gene Name=ATP13A2)
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