Structure of PDB 7n6x Chain A

Receptor sequence
>7n6xA (length=99) Species: 11686 (Human immunodeficiency virus type 1 (BRU ISOLATE)) [Search protein sequence]
PQITLWKRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKLIVGI
GGFVKVRQYEQVPIEIAGHKVVGTVLIGPTPSNIIGRNLMTQLGATLNF
3D structure
PDB7n6x Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 478 A D25 G27 D30 G49 I84 D25 G27 D30 G49 I84
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7n6x, PDBe:7n6x, PDBj:7n6x
PDBsum7n6x
PubMed34419931
UniProtP03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)

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