Structure of PDB 7n68 Chain A

Receptor sequence
>7n68A (length=181) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
PRGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVC
FMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKE
NRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLD
EESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB7n68 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 MN A H41 D108 E119 I120 H46 D94 E105 I106
BS02 MN A E80 D108 E66 D94
BS03 0VL A Y24 I38 H41 E80 D108 E119 Y29 I43 H46 E66 D94 E105
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function

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Biological Process
External links
PDB RCSB:7n68, PDBe:7n68, PDBj:7n68
PDBsum7n68
PubMed36603507
UniProtC3W5S0

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