Structure of PDB 7n4u Chain A

Receptor sequence
>7n4uA (length=953) Species: 9606 (Homo sapiens) [Search protein sequence]
THTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVEL
WSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNF
SGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSL
YDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTF
KDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAG
DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAED
LPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMA
AMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR
EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVIL
DFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFF
QKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSY
LLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQ
KIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCPS
TVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAY
STSVNLTSDGQVLTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRK
VPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLG
LDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFV
SHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKA
QLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEE
AVA
3D structure
PDB7n4u Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
ChainA
Resolution3.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A F1155 L1158 W1159 L1248 F823 L826 W827 L916
BS02 VIV A W383 T407 L621 Q873 L890 F1101 W51 T75 L289 Q541 L558 F769
Gene Ontology
Molecular Function
GO:0005319 lipid transporter activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7n4u, PDBe:7n4u, PDBj:7n4u
PDBsum7n4u
PubMed34407950
UniProtQ9UHC9|NPCL1_HUMAN NPC1-like intracellular cholesterol transporter 1 (Gene Name=NPC1L1)

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