Structure of PDB 7n4r Chain A

Receptor sequence
>7n4rA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEF
IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR
FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGL
SRYVLDKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF
TNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNI
LDVMDEE
3D structure
PDB7n4r Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0BG A L408 F413 V416 A428 K430 T474 Y476 M477 L528 D539 L16 F21 V24 A36 K38 T82 Y84 M85 L136 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7n4r, PDBe:7n4r, PDBj:7n4r
PDBsum7n4r
PubMed34314938
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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