Structure of PDB 7n47 Chain A

Receptor sequence
>7n47A (length=180) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
RGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDE
ESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB7n47 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H45 D93 E104 I105
BS02 MN A E80 D108 E65 D93
BS03 QQ4 A M12 F46 M16 F50
BS04 09Y A Y24 I38 H41 E80 D108 E119 Y28 I42 H45 E65 D93 E104
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7n47, PDBe:7n47, PDBj:7n47
PDBsum7n47
PubMed36603507
UniProtC3W5S0

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