Structure of PDB 7n42 Chain A

Receptor sequence
>7n42A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
DPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQT
LRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFH
HPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANS
VKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAAL
3D structure
PDB7n42 Crystal structure of the tandem bromodomain of human TAF1 (TAF1-T) bound to ZS1-681
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 06M A W1526 P1527 F1528 H1530 P1531 V1532 N1533 F1536 M1548 D1549 Y1582 N1583 Y1589 W147 P148 F149 H151 P152 V153 N154 F157 M169 D170 Y203 N204 Y210
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0005669 transcription factor TFIID complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7n42, PDBe:7n42, PDBj:7n42
PDBsum7n42
PubMed
UniProtP21675|TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (Gene Name=TAF1)

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