Structure of PDB 7n3u Chain A

Receptor sequence
>7n3uA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQN
ALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENY
RIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTNKVMF
KIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVC
AAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPS
AMALVKHSVLL
3D structure
PDB7n3u Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 05J A I305 F310 V313 A326 K328 N376 C379 G382 D386 F433 I13 F18 V21 A34 K36 N84 C87 G90 D94 F141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7n3u, PDBe:7n3u, PDBj:7n3u
PDBsum7n3u
PubMed34423975
UniProtP30291|WEE1_HUMAN Wee1-like protein kinase (Gene Name=WEE1)

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