Structure of PDB 7n18 Chain A

Receptor sequence
>7n18A (length=396) Species: 1491 (Clostridium botulinum) [Search protein sequence]
SSGLVPRGSHMEFVNKQFNYKDPVNGVDIAYIKIPMQPVKAFKIHNKIWV
IPERDTFTNPEEGDLNPPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYST
DLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNL
VIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLG
AGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKEVSFEELRTFGGHDA
KFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKY
LLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDK
AVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
3D structure
PDB7n18 Structure-based Drug Design of Chiral Inhibitors for the Inhibition of Botulinum Neurotoxin A
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H223 H227 E262 H214 H218 E241
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7n18, PDBe:7n18, PDBj:7n18
PDBsum7n18
PubMed34413962
UniProtP0DPI1|BXA1_CLOBH Botulinum neurotoxin type A (Gene Name=botA)

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