Structure of PDB 7mx0 Chain A

Receptor sequence

>7mx0A (length=180) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1)))

RGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDE
ESRARIKTRLFTIRQEMASRSLWDSFRQSE

3D structure

• PDB: 7mx0 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
• Chain: A
• Resolution: 2.48 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	H41 D108 E119 I120	H45 D93 E104 I105
BS02	MN	A	E80 P107 D108	E65 P92 D93
BS03	WTD	A	K34 I38 H41 E80 D108 E119	K38 I42 H45 E65 D93 E104
BS04	QQ4	A	M12 F46	M16 F50

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7mx0, PDBe:7mx0, PDBj:7mx0
• PDBsum: 7mx0
• UniProt: C3W5S0