Structure of PDB 7mvv Chain A

Receptor sequence

>7mvvA (length=1542) Species: 759272 (Thermochaetoides thermophila DSM 1495)

MTDLRKLEALQALHAELVAVRQHRFEGLQVLETLLEEQTDAFKALIAKPA
RDTKDREALGKEPKKLKIGEEEYSLNEDFVNDCLKLADELDLNEKESARI
LIDCDAEGDVETQSRPLWECGVIRFHQERKYLLDCMRLILEIAADEDIDA
GLQESFGVAAEDKIFGIPPPWERQVKKFIPRCMEAMKGVRSMLQCMADKA
NARNMLDNQETLDFSRLSLVEQHECLASILHAAVQRHHATIADFQDFIKI
LRKWDKYDHFLIHLIPVLAAYITEFGSPEGMGDLQQARRLNDFICSWALP
VLGAAVRAWWIAEHNGFYLDDTVQDLRGINLDEEDEQRTKQFLDALKEGA
FDFILSVAADCKAQEWQDPSQLGARQWLQRKIPSLPSEPFPFSHFLQHSL
MVHLEGFVDATISNLPDVLRKLRTEEDEQRQLRPNHEQDMDLERFLIIIS
YAYEGRPDAAMSFWEDPDSNLAGFLQWASRRASTPLVSAFCEMLRCLADN
EECATAAHNFLLDEQSLTWSQIFKELEYFTTKVCSEIEPESALMLECYLR
LIAKLATESEIARKRLIMDEDFNLVDTILKLSVGVIPHRLRACIFYVLKA
LMIRKTHEELDAMWRWVEAWMTNPFPGPQECMEMMFREFGTGFEQSNAFI
QLLTTLLVPPEGLNDSVPFPEWLGSSIRTLGIEPYVDFVFDVFANRTKDI
SDPSQLRILRLSCLDFVMVCLVTFNEDLIVLGHESNISIDDAMAATNLAT
YVRLHPFSRVMEWLFNEKVITSLINTIHQDPISLGSASPDSPLVVSILRA
IQVMIKALELQETYLHLVRPEVLRYQGEAGVRRKPVANAAYSAFEDGILS
HLSLVVDLGKYCNLGHAELTLACLKLLEKISTSSRILSAWSPRNKAIVQL
ERNGEGETISASLSASIMATLDPALAASGENYRVKLAILDFLYACLRATP
DQPTIAHQLLGFHCELSKLGIEPKGPFDMQKSLFHSLLNVLITLTVSEEE
QGMRGYLVTLKYRVLRILQLLWKSPLSASLVMDELRATNFLFHMLLREVQ
IQPQLPWDGQLVTGCEFLLSDASLAYIDYLASRAAIFEYIGKELCSVSQN
RIPSIKRQIFDALNGQIFVPLTIPSIFDFFDFINTDYKWEEIPSPHFTYL
KDLDLGPCIGVHYDIRKAQEILALKRKEYEHSQLATPEFLETVELEEKVL
IEWLTVRNRANLLLTARLNLLQAWANLLLVMIESNDFKSTPKMAFLLQAL
QAILPTLEAFSSLKSDEAFELARVAKVLLWKLEQFTVGNLIGDKLFQLFQ
LCLSAISQCSGTPELRSLYYSICYRYLTAVVDTRSVTNARARTLKAITLY
GDRLLNVICDDAYGSDTTCQTAAMILLNALVHTSRASVDCPIIDALNRLN
FIGVLVDSLKEILNEWASPSQQYTSAKLALLLQLCQTRQGAKYVLQANLF
RALEQSGVFVVALERHYALLVALARVVGAAVTARGAHNIVQGRKFLTQHR
GLVVHVLKKNAILAQQALEERIEELAEAFMLLITATGFLEYE

3D structure

• PDB: 7mvv Architecture of the linker-scaffold in the nuclear pore.
• Chain: A
• Resolution: 3.22 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	P438 R442 N492 F496	P416 R420 N470 F474
BS02	peptide	A	Q1063 N1072 T1121 F1125 H1126 V1202	Q980 N989 T1038 F1042 H1043 V1119

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0017056 structural constituent of nuclear pore

Biological Process

• GO:0006913 nucleocytoplasmic transport
• GO:0006999 nuclear pore organization
• GO:0015031 protein transport
• GO:0051028 mRNA transport

Cellular Component

• GO:0005634 nucleus
• GO:0005643 nuclear pore
• GO:0044611 nuclear pore inner ring

External links

• PDB: RCSB:7mvv, PDBe:7mvv, PDBj:7mvv
• PDBsum: 7mvv
• PubMed: 35679425
• UniProt: G0S4T0|NU192_CHATD Nucleoporin NUP192 (Gene Name=NUP192)