Structure of PDB 7mvs Chain A

Receptor sequence
>7mvsA (length=674) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
GKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVE
KARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAH
IRTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPE
HRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYARINERNITS
EMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKK
SARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGD
GAAAMRFTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPN
LLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGP
DFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPF
QVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASV
ILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRR
TQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFK
LSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLL
QLVRDELTEIRDRFGDDRRTEIQL
3D structure
PDB7mvs Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
ChainA
Resolution2.60137 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:7mvs, PDBe:7mvs, PDBj:7mvs
PDBsum7mvs
PubMed34614347
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB);
P20831

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