Structure of PDB 7mty Chain A

Receptor sequence
>7mtyA (length=181) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
PRGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVC
FMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKE
NRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLD
EESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB7mty Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QQ4 A M12 F46 M17 F51
BS02 MN A H41 D108 E119 I120 H46 D94 E105 I106
BS03 MN A E80 D108 E66 D94
BS04 W5V A H41 E80 D108 E119 H46 E66 D94 E105
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7mty, PDBe:7mty, PDBj:7mty
PDBsum7mty
PubMed36603507
UniProtC3W5S0

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