Structure of PDB 7msr Chain A

Receptor sequence
>7msrA (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
SYTASRQHLYVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKG
GQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAIEAEIPLVV
CITQGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVINPGECKIGIMPGHIH
KKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLE
IFLNDSATEGIILIGEIGGNAEENAAEFLKQHNSGPNSKPVVSFIAGLTA
PPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFE
KRKMLEH
3D structure
PDB7msr The structure of succinyl-CoA synthetase bound to the succinyl-phosphate intermediate clarifies the catalytic mechanism of ATP-citrate lyase
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.4: succinate--CoA ligase (GDP-forming).
6.2.1.5: succinate--CoA ligase (ADP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DCA A G22 T24 K26 Q27 P48 K50 V80 P81 I103 T104 Q105 N131 G21 T23 K25 Q26 P47 K49 V79 P80 I102 T103 Q104 N130
BS02 ZNS A S162 G163 T164 Y167 H259 S161 G162 T163 Y166 H258
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:7msr, PDBe:7msr, PDBj:7msr
PDBsum7msr
PubMed
UniProtP53597|SUCA_HUMAN Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (Gene Name=SUCLG1)

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