Structure of PDB 7mso Chain A

Receptor sequence
>7msoA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYG
LGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSL
MKKITLLKYFRNYMSEHLLKAGANITPARLPYLRTWFRTRSAIILHLSNG
SVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELAS
RLRYARTMVDKLLS
3D structure
PDB7mso Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W414 V415 D416 Y485 E488 H489 L490 L491 R516 H538 K540 W42 V43 D44 Y113 E116 H117 L118 L119 R138 H160 K162
External links
PDB RCSB:7mso, PDBe:7mso, PDBj:7mso
PDBsum7mso
PubMed35029981
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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