Structure of PDB 7moz Chain A

Receptor sequence
>7mozA (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
GKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRP
HKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGL
FEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDI
VLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFP
GTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSA
VVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIR
NVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTP
EYMEKIKQRLFENLRMLP
3D structure
PDB7moz Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
ChainA
Resolution1.543 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D177 H179 D265 D170 H172 D258
BS02 CA A D175 D177 H179 S198 F199 D168 D170 H172 S191 F192
BS03 CA A F188 V194 Y223 F181 V187 Y216
BS04 ZL4 A G28 H29 P30 E99 D100 H141 H142 G150 F151 H179 F206 L272 G302 Y304 G21 H22 P23 E92 D93 H134 H135 G143 F144 H172 F199 L265 G295 Y297
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:7moz, PDBe:7moz, PDBj:7moz
PDBsum7moz
PubMed34091041
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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