Structure of PDB 7mow Chain A

Receptor sequence
>7mowA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
ASMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRD
VSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEM
VWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISED
IKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKV
RESGSLSPEHGPVVVHCSAGIGRSGTICLADTCLLLMDKRKDPSSVDIKK
VLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
3D structure
PDB7mow Conserved conformational dynamics determine enzyme activity.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OTA A Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y48 D50 K122 D183 F184 C217 S218 A219 I221 G222 R223 Q264
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7mow, PDBe:7mow, PDBj:7mow
PDBsum7mow
PubMed35921420
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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