Structure of PDB 7mo7 Chain A

Receptor sequence
>7mo7A (length=637) Species: 9606 (Homo sapiens) [Search protein sequence]
KRRNTIHEFKKSAKTTLIKIDPIKTKKVNTADQCANRCTRNKGLPFTCKA
FVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSY
KGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGG
PWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWD
HQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIK
TCADTTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFENY
CRNPDGSESPWCFTTDPNIRVGYCSQIPNCDQDCYRGNGKNYMGNLSQTR
SGLTCSMWDKNMEDLHRHIFWEPKLNENYCRNPDDDAHGPWCYTGNPLIP
WDYCPISRCVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQC
FPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLA
RPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLY
IMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMR
MVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILT
3D structure
PDB7mo7 Structural basis of the activation of c-MET receptor.
ChainA
Resolution4.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q534 D578 E670 G671 D672 Y673
Catalytic site (residue number reindexed from 1) Q449 D493 E585 G586 D587 Y588
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SGN A K62 R73 K26 R37
BS02 SGN A R35 R76 N77 R2 R40 N41
BS03 IDS A K34 R36 K1 R3
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7mo7, PDBe:7mo7, PDBj:7mo7
PDBsum7mo7
PubMed34210960
UniProtP14210|HGF_HUMAN Hepatocyte growth factor (Gene Name=HGF)

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