Structure of PDB 7mmz Chain A

Receptor sequence
>7mmzA (length=559) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1) [Search protein sequence]
TATEEYLSEFWSEIAAQTIDWIQPWSITLQGGLHKGDVKWFQGGLLNVSA
NCLDRHLPHKANQTAIIWEGDDENQNKTLTFAQLYSEVCKMSNVLKSLNV
RRGDTVGIYLPMIPEAAIAMLACARIGAIHTVVFAGFSAHALQQRLIASS
CKCLITADAFQRGGKTIPLKKQADEASVDLNITKLVVKNSNAPTALNKNK
EHWWHELKQTVSDQCTPEPMNTEDPLFILYTSGSTGQPKGVVHTTGGYLV
QAAYTHQLIFACQDNEVFWCTADVGWITGHSYVVYGPLCNGITTLMFEGI
PTWPDAARNWRIIDKHQVNVFYTAPTAIRSLMRAGDQWLNSSSRSSLRLL
GSVGEPINPEAWNWYHQKVGQGKCPIVDTWWQTETGAIMISPRASDEVIK
PGSARKPIPGIVPLLLNEQGHEINGAGEGLLAIKYPWPSMARTIAGDHQR
YCNTYLSNGYYITGDGAKRDEDGDYWITGRIDDVLNVSGHRLGTAEIESA
LVSHPKVAEAGVVGIPHDLKGQAIFAYVILPDAELQTELMERVKDQISAI
AKPDVIQFA
3D structure
PDB7mmz Bacterial structural genomics target enabled by a recently discovered potent fungal acetyl-CoA synthetase inhibitor.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T242 T394 E395 N497 R502
Catalytic site (residue number reindexed from 1) T231 T383 E384 N486 R491
Enzyme Commision number 6.2.1.1: acetate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WTA A I288 G365 E366 P367 T390 W391 W392 Q393 T394 D476 I488 R491 R502 I277 G354 E355 P356 T379 W380 W381 Q382 T383 D465 I477 R480 R491
Gene Ontology
Molecular Function
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016208 AMP binding
GO:0016874 ligase activity
Biological Process
GO:0006085 acetyl-CoA biosynthetic process
GO:0019427 acetyl-CoA biosynthetic process from acetate

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Molecular Function
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Biological Process
External links
PDB RCSB:7mmz, PDBe:7mmz, PDBj:7mmz
PDBsum7mmz
PubMed37223974
UniProtQ5ZZ84

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