Structure of PDB 7ml7 Chain A

Receptor sequence

>7ml7A (length=1216) Species: 1496 (Clostridioides difficile)

MSLVNRKQLEKMANVRFRTQEDEYVAILDALEEYHNMSENTVVEKYLKLK
DINSLTDIYIDTYKKSGRNKALKKFKEYLVTEVLELKNNNLTPVEKNLHF
VAIGGQINDTAINYINQWKDVNSDYNVNVFYDSNAFLINTLKKTVVESAI
NDTLESFRENLNDPRFDYNKFFRKRMEIIYDKQKNFINYYKAQREENPEL
IIDDIVKTYLSNEYSKEIDELNTYIEESLNKITQNSGNDVRNFEEFKNGE
SFNLYEQELVERWNLAAASDILRISALKEIGGMYLNVNMLPGIQPDLFES
IEKPSSVTVDFWEMTKLEAIMKYKEYIPEYTSEHFDMLDEEVQSSFESVL
ASKSDKSEIFSSLGDMEASPLEVKIAFNSKGIINQGLISVKDSYCSNLIV
KQIENRYKILNNSLNPAISEDNDFNTTTNTFIDSIMAEANADNGRFMMEL
GKYLRVGFFPDVKTTINLSGPEAYAAAYQDLLMFKEGSMNIHLIEADLRN
FEISKTNISQSTEQEMASLWSFDDARAKAQFEEYKRNYFEGSAGEDDNLD
FSQNIVVDKEYLLEKISSLARSSERGYIHYIVQLQGDKISYEAACNLFAK
TPYDSVLFQKNIEDSEIAYYYNPGDGEIQEIDKYKIPSIISDRPKIKLTF
IGHGKDEFNTDIFAGFDVDSLSTEIEAAIDLAKEDISPKSIEINLLGCNM
FSYSINVEETYPGKLLLKVKDKISELMPSISQDSIIVSANQYEVRINSEG
RRELLDHSGEWINKEESIIKDISSKEYISFNPKENKITVKSKNLPELSTL
LQEIRNNSNSSDIELEEKVMLTECEINVISNIDTQINYIKDEFKLIESIS
DALCDLKQQNILTGYYLKDDIKISLSLTLQDEKTIKLNSVHLDESGVAEI
LKFMNRKGLMSFLESMNIKSNIKFILDANFIISGTTSIGQFEFICDENDN
IQPYFIKFNTLETNYTLYVGNRQNMIVEPNYDLDDSGDISSTVINFSQKY
LYGIDSCVNKVVISPNIYTDEINITPVYETNNTYPEVIVLDANYINEKIN
VNINDLSIRYVWSNDGNDFILMSTSEENKVSQVKIRFVNVFKDKTLANKL
SFNFSDKQDVPVSEIILSFTPSYYEDGLIGYDLGLVSLYNEKFYINNFGM
MVSGLIYINDSLYYFKPPVNNLITGFVTVGDDKYYFNPINGGAASIGETI
IDDKNYYFNQSGVLQT

3D structure

• PDB: 7ml7 Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
• Chain: A
• Resolution: 3.17 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.-
  3.4.22.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D546 H653 C698 H757	D546 H653 C698 H757

Gene Ontology

Molecular Function

• GO:0016757 glycosyltransferase activity

External links

• PDB: RCSB:7ml7, PDBe:7ml7, PDBj:7ml7
• PDBsum: 7ml7
• PubMed: 34145250
• UniProt: P18177|TCDB_CLODI Toxin B (Gene Name=tcdB)