Structure of PDB 7miy Chain A

Receptor sequence

>7miyA (length=1326) Species: 9606 (Homo sapiens)

KYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEP
YFIGIFCFEAGIKIIALGFVSYLRNGWNVMDFVVVLTGILATAGTDFDLR
TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAI
IGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPG
PNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL
IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYL
EWIFKAEEVMLAEEDRNFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNT
LCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSF
NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLR
NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNF
DTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFG
NYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSP
MSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALRRFCHYIVT
MRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEM
VIKMIDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKT
IKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC
TDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTV
STGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIF
VALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQ
YKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFT
SMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNF
INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF
IYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIM
LSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF
EYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLG
LGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAG
TKQHQCDAELRKEISVVWANLPQKTL

3D structure

• PDB: 7miy Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E314 E663 E1365	E225 E517 E854
BS02	Y01	A	F617 P650 I653 L654 S1393 I1394	F471 P504 I507 L508 S882 I883
BS03	CLR	A	F1296 E1391 F1395	F785 E880 F884
BS04	CLR	A	V1486 M1490 F1492	V975 M979 F981
BS05	Y01	A	H503 L1352	H357 L841
BS06	Y01	A	A1169 F1611 F1641	A671 F1100 F1130
BS07	CLR	A	L1162 R1179	L664 R681
BS08	CLR	A	D1682 F1683 F1686	D1171 F1172 F1175
BS09	PT5	A	S544 F546 L583 R584 K587 W592 V599	S398 F400 L437 R438 K441 W446 V453

Gene Ontology

Molecular Function

• GO:0001540 amyloid-beta binding
• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005262 calcium channel activity
• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008331 high voltage-gated calcium channel activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006816 calcium ion transport
• GO:0007268 chemical synaptic transmission
• GO:0050804 modulation of chemical synaptic transmission
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport
• GO:0098703 calcium ion import across plasma membrane
• GO:1904645 response to amyloid-beta

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane
• GO:0034702 monoatomic ion channel complex
• GO:0043025 neuronal cell body
• GO:0045202 synapse

External links

• PDB: RCSB:7miy, PDBe:7miy, PDBj:7miy
• PDBsum: 7miy
• PubMed: 34234349
• UniProt: Q00975|CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B (Gene Name=CACNA1B)