Structure of PDB 7mgw Chain A

Receptor sequence
>7mgwA (length=537) Species: 9606 (Homo sapiens) [Search protein sequence]
RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFG
GIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNT
IMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPA
EEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSG
KVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWID
AAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV
IFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFF
LMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSL
VTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEM
LGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILG
YCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPE
3D structure
PDB7mgw Illumination of serotonin transporter mechanism and role of the allosteric site.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CL A F105 Y121 S372 F27 Y43 S294
BS02 SRO A Y95 D98 A169 I172 A173 F335 F341 S438 T439 G442 Y17 D20 A91 I94 A95 F257 F263 S360 T361 G364
BS03 SRO A E494 Y495 P499 F556 P561 Y579 E416 Y417 P421 F478 P483 Y501
BS04 CLR A L89 Y289 L11 Y211
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7mgw, PDBe:7mgw, PDBj:7mgw
PDBsum7mgw
PubMed34851672
UniProtP31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)

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