Structure of PDB 7mdn Chain A

Receptor sequence
>7mdnA (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
KDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKSARQYHVQFF
GDAPERAWIFEKSLVAFEGEGQFEKLCQESAKTKAEKIKLLKPISGKLRA
QWEMGIVQAEEAASMSVEERKAKFTFLY
3D structure
PDB7mdn A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y6V A V230 Y233 W236 F266 F267 G268 A270 E272 L318 Q321 V17 Y20 W23 F49 F50 G51 A53 E55 L98 Q101
BS02 Y6V A K317 A320 K97 A100
External links
PDB RCSB:7mdn, PDBe:7mdn, PDBj:7mdn
PDBsum7mdn
PubMed34782742
UniProtO96028|NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (Gene Name=NSD2)

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