Structure of PDB 7mdc Chain A

Receptor sequence
>7mdcA (length=438) Species: 562 (Escherichia coli) [Search protein sequence]
IGAQDERLSTLIHQRMQEAKVPALSVSVTIKGVRQRFVYGVADVASQKAN
TLDTVYELGSMSKAFTGLVVQILIQEGRLRQGDDIITYLPEMRLNYQGKP
ASLTVADFLYHTSGLPFSTLARLENPMPGSAVAQQLRNENLLFAPGAKFS
YASANYDVLGAVIENVTGKTFTEVIAERLTQPLGMSATVAVKGDEIIVNK
ASGYKLGFGKPVLFHAPLARNHVPAAYIHSTLPDMEIWIDAWLHRKALPA
TLREAMSNSWRGNSDVPLAADNRILYASGWFIDQNQGPYISHGGQNPNFS
SCIALRPDQQIGIVALANMNSNLILQLCADIDNYLRIGKYADGAGDAITA
TDTLFVYLTLLLCFWGAVVVVRGAFRVRDYIIALAVPGLVAAMLYVAPGI
LSPGLDWRFILVWGPSSVLAIPFGIILLAFVLTLNHQI
3D structure
PDB7mdc A small molecule inhibitor prevents gut bacterial genotoxin production.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 97N A W460 L464 W407 L411
BS02 YX7 A S95 L155 Y186 S188 H257 A261 Q330 N331 W466 S60 L120 Y151 S153 H222 A226 Q295 N296 W413
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mdc, PDBe:7mdc, PDBj:7mdc
PDBsum7mdc
PubMed36253549
UniProtQ0P7K6

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