Structure of PDB 7md4 Chain A

Receptor sequence
>7md4A (length=724) Species: 9606 (Homo sapiens) [Search protein sequence]
VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIM
ITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGL
YNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLCKSHGCTAE
GLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCV
NFSFCQDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCEKTIDS
VTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRS
YALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQ
GKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELL
KFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVVVDIDPPL
RSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYV
QTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAED
SELFELDYCLKGLKLPSREEHRPFEKVVNKESLVISGLRHFTGYRIELQA
CNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEP
KEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYL
3D structure
PDB7md4 Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
ChainA
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F88 F89 R118 Y144 F82 F83 R112 Y138
BS02 peptide A R479 K484 R406 K411
BS03 peptide A D12 R14 F39 D6 R8 F33
External links
PDB RCSB:7md4, PDBe:7md4, PDBj:7md4
PDBsum7md4
PubMed35177603
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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