Structure of PDB 7mcj Chain A

Receptor sequence
>7mcjA (length=276) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PFYEQSIYDVSDEFFSLFLDPTMAYTCAYFEREDMTLEEAQNAKFDLALD
KLHLEPGMTLLDIGCGWGGGLQRAIENYDVNVIGITLSRNQFEYSKAKLA
KIPTERSVQVRLQGWDEFTDKVDRIVSIGAFEAFKMERYAAFFERSYDIL
PDDGRMLLHTILTYTQKQMHEMGVKVTMSDVRFMKFIGEEIGQLPAQEDI
FKFAQAADFSVEKVQLLQQHYARTLNIWAANLEANKDRAIALQSEEIYNK
YMHYLTGCEHFFRKGISNVGQFTLTK
3D structure
PDB7mcj Crystal Structure of S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis in complex with compound 8918
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FD7 A Y32 G136 E139 I168 Y231 L235 W238 Y264 L265 C268 Y25 G129 E132 I161 Y221 L225 W228 Y254 L255 C258
BS02 MG A G71 I135 G64 I128
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
GO:0032259 methylation
GO:0071768 mycolic acid biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mcj, PDBe:7mcj, PDBj:7mcj
PDBsum7mcj
PubMed
UniProtQ6MX39|UMAA_MYCTU S-adenosylmethionine-dependent methyltransferase UmaA (Gene Name=umaA)

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