Structure of PDB 7mbv Chain A

Receptor sequence
>7mbvA (length=996) Species: 7955 (Danio rerio) [Search protein sequence]
RLGDIDFTGVSRTRGKFVRVTSSTDPAEIYQILTKQWGLAPPHLVVALMG
GDEVAQLKPWLRDTLRKGLVKAAQSTGAWILTSGLRFGITKNLGQAVRDH
SLASTSPKVRVVAIGIAPWNMIQNRDLLLSAKPDHPATYPTEDLPYGAVY
SLDCNHSHFILVDEDPKRPGATGEMRVKMLKHISLQRTGYGGTGSIEIPV
LCLLVHGEPRILQKMYKNIQNSIPWLILAGSGGVADILVTLMDRGCWDAD
IVQELLINTFPDGLHSTEITSWTKLIQRILDHGHLLTVHDPEQDSELDTV
ILKALVKACKSQSQEAQDFLDELKLAVAWNRVDIAKSEIFSGDVQWSAQD
LEEVMMEALVNDKPDFVRLFVDNGVNIKQFLTYGRLQELYCSVSEKNLLH
TLLLKKNQERQAQLKFRFTFHEVSKVLKDFLDDTCKGFYQKLNLPDMDRR
CEHPWRDLFLWAILQNRQEMANYFWAMGPEAVAAALVGCKIMKEMAHLAT
EAESARSMKNAKYEQFAMDLFSECYSNSEDRAYSLLVRKTCCWSKATVLN
IATLAEAKCFFAHDGVQALLTKVWWGAMRTDTSISRLVLTFFIPPLVWTS
LIKFNPESATFIRVVLRRWNRFWSAPVTVFMGNVIMYFAFLILFSYVLLL
DFRPPPPYGPSAAEIILYFWVFTLVLEEIRQSFFTDEDMSILKKMKLYVE
DNWNKCDMVAISLFVVGLSCRMAMSTYEAGRTVLALDFMVFTLRLIHIFA
IHKQLGPKIIIVERMIKDVFFFLFFLSVWLIAYGVTTQALLHPNDPRIDW
VFRRALYRPYLHIFGQIPLEEIDAAKMPDDNCTTDVQEIILGTLPPCPNI
YANWLVILLLVIYLLVTNVLLLNLLIAMFSYTFQVVQENADIFWKFQRYN
LIVEYHSRPALAPPFIIISHITQALLSFIKDLLERELPSGLDQKLMTWET
VQKENYLAKLEHEHRESSGERLRYTSSKVQTLLRMVGGFKDQEKRM
3D structure
PDB7mbv Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E768 N794 D797 E678 N704 D707
BS02 CA A E212 C324 D333 D336 E337 E197 C309 D318 D321 E322
BS03 YUS A W793 I836 I849 V852 E853 W703 I746 I759 V762 E763
BS04 YUY A A914 A915 M917 W944 I947 A824 A825 M827 W854 I857
BS05 YUY A W890 F892 L896 Y900 W800 F802 L806 Y810
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0019722 calcium-mediated signaling
GO:0034220 monoatomic ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mbv, PDBe:7mbv, PDBj:7mbv
PDBsum7mbv
PubMed34168372
UniProtS5UH55

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