Structure of PDB 7mbo Chain A

Receptor sequence
>7mboA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVNYTDSQRPISLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQA
3D structure
PDB7mbo Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
ChainA
Resolution0.924 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YXG A L41 H57 Y143 A190 C191 K192 G193 S195 T213 W215 G216 G218 C219 G226 V227 Y228 L28 H44 Y134 A183 C184 K185 G186 S188 T206 W208 G209 G211 C212 G219 V220 Y221 BindingDB: Ki=0.100nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7mbo, PDBe:7mbo, PDBj:7mbo
PDBsum7mbo
PubMed34494428
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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