Structure of PDB 7m94 Chain A

Receptor sequence
>7m94A (length=163) Species: 9913 (Bos taurus) [Search protein sequence]
GTLGARRGLEWFLGFYFLSHIPITLLMDLQGVLPRDLYPVELRNLQQWYI
EEFKDPLLQTPPAWFKSFLFCELVFQLPFFPIAAYAFFKGGCKWIRTPAI
IYSVHTMTTLIPILSTLLLDDFSKRGQGPKTFQERLFLISVYIPYFLIPL
ILLLFMVRNPYYK
3D structure
PDB7m94 Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
ChainA
Resolution2.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YT7 A M28 D29 Y50 Q77 Y147 Y150 M27 D28 Y49 Q76 Y142 Y145
Gene Ontology
Molecular Function
GO:0008142 oxysterol binding
GO:0015485 cholesterol binding
Biological Process
GO:0032377 regulation of intracellular lipid transport
GO:0032383 regulation of intracellular cholesterol transport
GO:0042632 cholesterol homeostasis
GO:0090303 positive regulation of wound healing
GO:0140077 positive regulation of lipoprotein transport
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0031965 nuclear membrane

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Cellular Component
External links
PDB RCSB:7m94, PDBe:7m94, PDBj:7m94
PDBsum7m94
PubMed34880501
UniProtQ3MHW7|SGMR2_BOVIN Sigma intracellular receptor 2 (Gene Name=TMEM97)

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