Structure of PDB 7m7f Chain A

Receptor sequence
>7m7fA (length=1390) Species: 1836 (Saccharopolyspora erythraea) [Search protein sequence]
MASTDSEKVAEYLRRATLDLRAARQRIRELEGEPVAVVAMACRLPGGVST
PEEFWELLSEGRDAVAGLPTDRGWDLDSLFHPDPTRSGTAHQRGGGFLTE
ATAFDPAFFGMSPREALAVDPQQRLMLELSWEVLERAGIPPTSLQASPTG
VFVGLIPQEYGPRLAEGGEGVEGYLMTGTTTSVASGRIAYTLGLEGPAIS
VDTACSSSLVAVHLACQSLRRGESSLAMAGGVTVMPTPGMLVDFSRMNSL
APDGRCKAFSAGANGFGMAEGAGMLLLERLSDARRNGHPVLAVLRGTAVN
SDGASNGLSAPNGRAQVRVIQQALAESGLGPADIDAVEAHGTGTRLGDPI
EARALFEAYGRDREQPLHLGSVKSNLGHTQAAAGVAGVIKMVLAMRAGTL
PRTLHASERSKEIDWSSGAISLLDEPEPWPAGARPRRAGVSSFGISGTNA
HAIIEEAPQVVEGERVEAGDVVAPWVLSASSAEGLRAQAARLAAHLREHP
GQDPRDIAYSLATGRAALPHRAAFAPVDESAALRVLDGLATGNADGAAVG
TSRAQQRAVFVFPGQGWQWAGMAVDLLDTSPVFAAALRECADALEPHLDF
EVIPFLRAEAARREQDAALSTERVDVVQPVMFAVMVSLASMWRAHGVEPA
AVIGHSQGEIAAACVAGALSLDDAARVVALRSRVIATMPGNKGMASIAAP
AGEVRARIGDRVEIAAVNGPRSVVVAGDSDELDRLVASCTTECIRAKRLA
VDYASHSSHVETIRDALHAELGEDFHPLPGFVPFFSTVTGRWTQPDELDA
GYWYRNLRRTVRFADAVRALAEQGYRTFLEVSAHPILTAAIEEIGDGSGA
DLSAIHSLRRGDGSLADFGEALSRAFAAGVAVDWESVHLGTGARRVPLPT
YPFQRERVWLEPKPVARRSTEVDEVSALRYRIEWRPTGAGEPARLDGTWL
VAKYAGTADETSTAAREALESAGARVRELVVDARCGRDELAERLRSVGEV
AGVLSLLAVDEAEPEEAPLALASLADTLSLVQAMVSAELGCPLWTVTESA
VATGPFERVRNAAHGALWGVGRVIALENPAVWGGLVDVPAGSVAELARHL
AAVVSGGAGEDQLALRADGVYGRRWVRAAAPATDDEWKPTGTVLVTGGTG
GVGGQIARWLARRGAPHLLLVSRSGPDADGAGELVAELEALGARTTVAAC
DVTDRESVRELLGGIGDDVPLSAVFHAAATLDDGTVDTLTGERIERASRA
KVLGARNLHELTRELDLTAFVLFSSFASAFGAPGLGGYAPGNAYLDGLAQ
QRRSDGLPATAVAWGTWAGSGMAEGPVADRFRRHGVIEMPPETACRALQN
ALDRAEVCPIVIDVRWDRFLLAYTAQRPTRLFDEIDDARR
3D structure
PDB7m7f Mapping the catalytic conformations of an assembly-line polyketide synthase module.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.94: 6-deoxyerythronolide-B synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PN7 A C205 S249 S309 P311 H340 T342 L346 G444 I445 C205 S249 S309 P311 H340 T342 L346 G444 I445
Gene Ontology
Molecular Function
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0031177 phosphopantetheine binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0009058 biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7m7f, PDBe:7m7f, PDBj:7m7f
PDBsum7m7f
PubMed34735239
UniProtQ03131|ERYA1_SACER 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 (Gene Name=eryA);
Q03133|ERYA3_SACER 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6 (Gene Name=eryA)

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