Structure of PDB 7m6t Chain A

Receptor sequence
>7m6tA (length=154) Species: 9606 (Homo sapiens) [Search protein sequence]
QQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDY
LLTISVKTSAGPTNLRIEYQDGKFRLDSIICVALAAFDSVVHLIDYYVQM
CKDKHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEY
KFQV
3D structure
PDB7m6t Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
ChainA
Resolution3.194 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A A33 L36 D74 D79 L81 Y99 A3 L6 D44 D49 L51 Y69
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:7m6t, PDBe:7m6t, PDBj:7m6t
PDBsum7m6t
PubMed34857742
UniProtO14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (Gene Name=SOCS2)

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