Structure of PDB 7m6k Chain A

Receptor sequence
>7m6kA (length=303) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
YLEKINEVIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQF
SSAQLLEQCLTTENRKHVVDNGLDKVVNVACVCTKNSNMEHSRVGTGILE
HLFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALANLSLYGGA
ENQEEMILRKVPMWLFPLAFHNDDNIKYYACLAIAVLVANKEIEAEVLKS
GCLDLVEPFVTSHDPSAFARSNLAHAHGQSKHWLKRLVPVLSSNREEARN
LAAFHFCMEAGIKREQGNTDIFREINAIEALKNVASCPNAIASKFAAQAL
RLI
3D structure
PDB7m6k Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
ChainA
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YRJ A W385 H392 Y396 E429 Q430 C431 L432 T433 R437 H473 K476 H599 S602 W13 H20 Y24 E57 Q58 C59 L60 T61 R65 H101 K104 H227 S230
Gene Ontology
Molecular Function
GO:0003953 NAD+ nucleosidase activity
GO:0035591 signaling adaptor activity
Biological Process
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0048678 response to axon injury

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Molecular Function
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Biological Process
External links
PDB RCSB:7m6k, PDBe:7m6k, PDBj:7m6k
PDBsum7m6k
PubMed34870595
UniProtQ6IDD9|SARM1_DROME NAD(+) hydrolase sarm1 (Gene Name=Sarm)

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