Structure of PDB 7m5z Chain A

Receptor sequence
>7m5zA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
LEDVVIDRNLLILGRILGEGEFGSVMEGNLKQEDGTSLKVAVKTMNSSQR
EIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDL
HTYLLYSRLETGPRHIPLQTLLRFMVDIALGMEYLSNRNFLHRDLAARNC
MLRDDMTVCVADFPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMT
PYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSV
LRLQLERLLESLP
3D structure
PDB7m5z Development of [ 18 F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.
ChainA
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YR7 A V601 A617 M674 K675 G677 M730 V25 A41 M95 K96 G98 M151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7m5z, PDBe:7m5z, PDBj:7m5z
PDBsum7m5z
PubMed34563964
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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