Structure of PDB 7m4m Chain A

Receptor sequence
>7m4mA (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
DELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCE
ELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQM
CYLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQK
EAEEEQKRKNGENTFKRIGPPLE
3D structure
PDB7m4m Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
ChainA
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C605 C623 C628 C6 C24 C29
BS02 ZN A C633 H643 C648 C34 H44 C49
BS03 ZN A C675 C678 C693 C695 C76 C79 C94 C96
BS04 ZN A C700 H712 C730 C101 H113 C131
BS05 ZN A C714 H716 C727 C115 H117 C128
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7m4m, PDBe:7m4m, PDBj:7m4m
PDBsum7m4m
PubMed34998453
UniProtQ9NWF9|RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (Gene Name=RNF216)

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