Structure of PDB 7m4k Chain A

Receptor sequence

>7m4kA (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]

NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQ
MWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQ
KAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
LRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLY
FTGSAHFNRSMRALAKTKGMSLSEHALSTAVPGRVLPTPTEKDVFRLLGL
PYREPAERDW

3D structure

PDB

7m4k Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints.

Chain

Resolution

1.719 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	W274 V462 G464 K472 R514 R517 K521 L527 E529 H530	W24 V212 G214 K217 R259 R262 K266 L272 E274 H275
BS02	dna	A	W342 G343 A344 G345 K347 T348 R488 D490 Y505	W92 G93 A94 G95 K97 T98 R233 D235 Y250
BS03	dna	A	Y267 W274 R275 Y279 P303 G304 G306 R308 M309 K312	Y17 W24 R25 Y29 P53 G54 G56 R58 M59 K62
BS04	CA	A	D427 D429	D177 D179
BS05	YQS	A	R386 G416 S417 R420 G426 D427 D429 Y505 T507 G508 A510 N513	R136 G166 S167 R170 G176 D177 D179 Y250 T252 G253 A255 N258

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7m4k, PDBe:7m4k, PDBj:7m4k
PDBsum	7m4k
PubMed	35680862
UniProt	Q9UGP5\|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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