Structure of PDB 7m47 Chain A

Receptor sequence

>7m47A (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]

NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQ
MWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQ
KAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
LRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLY
FTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGAKVGPGRVLPTPT
EKDVFRLLGLPYREPAERDW

3D structure

PDB

7m47 Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints.

Chain

Resolution

1.648 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	W274 V462 G464 T471 K472 R514 R517 K521 L527 S528 E529 H530 H541	W24 V212 G214 T216 K217 R259 R262 K266 L272 S273 E274 H275 H286
BS02	dna	A	W342 G343 A344 G345 K347 T348 D427 D429 D490 Y505 F506 T507 G508 A510 N513	W92 G93 A94 G95 K97 T98 D177 D179 D235 Y250 F251 T252 G253 A255 N258
BS03	dna	A	Y267 W274 R275 Y279 P303 G304 G306 R308 M309 K312	Y17 W24 R25 Y29 P53 G54 G56 R58 M59 K62
BS04	MG	A	D427 D429	D177 D179
BS05	PPV	A	S417 R420 D427	S167 R170 D177

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7m47, PDBe:7m47, PDBj:7m47
PDBsum	7m47
PubMed	35680862
UniProt	Q9UGP5\|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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