Structure of PDB 7m46 Chain A

Receptor sequence

>7m46A (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]

NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQ
MWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQ
KAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
LRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLY
FTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGAKVGPGRVLPTPT
EKDVFRLLGLPYREPAERDW

3D structure

PDB

7m46 Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints.

Chain

Resolution

1.92 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	W274 V462 G464 E470 T471 K472 R514 R517 K521 L527 S528 E529 H530 H541	W24 V212 G214 E215 T216 K217 R259 R262 K266 L272 S273 E274 H275 H286
BS02	dna	A	W342 G343 A344 G345 K347 T348 D427 D429 D490 Y505 T507 G508 A510 N513	W92 G93 A94 G95 K97 T98 D177 D179 D235 Y250 T252 G253 A255 N258
BS03	dna	A	Y267 W274 R275 G278 Y279 P303 G304 G306 R308 M309 K312	Y17 W24 R25 G28 Y29 P53 G54 G56 R58 M59 K62
BS04	MG	A	D427 D429	D177 D179
BS05	PPV	A	R386 G416 S417 R420 D427	R136 G166 S167 R170 D177

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7m46, PDBe:7m46, PDBj:7m46
PDBsum	7m46
PubMed	35680862
UniProt	Q9UGP5\|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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