Structure of PDB 7m3h Chain A

Receptor sequence
>7m3hA (length=409) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
RFYQMSPEERLASLLNEGQISADTKKEFENTALSSQIANHMIENQISETE
VPMGVGLHLTVDETDYLVPMATEEPSVIAALSNGAKIAQGFKTVNQQRLM
RGQIVFYDVADPESLIDKLQVREAEIFQQAELSYPSIVKRGGGLRDLQYR
AFDESFVSVDFLVDVKDAMGANIVNAMLEGVAELFREWFAEQKILFSILS
NYATESVVTMKTAIPVSRLSKGSNGREIAEKIVLASRYASLDPYRAVTHN
KGIMNGIEAVVLATGNDTRAVSASCHAFAVKEGRYQGLTSWTLDGEQLIG
EISVPLALATVGGATKVLPKSQAAADLLAVTDAKELSRVVAAVGLAQNLA
ALRALVSEGIQKGHMALQARSLAMTVGATGKEVEAVAQQLKRQKTMNQDR
ALAILNDLR
3D structure
PDB7m3h Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
ChainA
Resolution1.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.9: acetyl-CoA C-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YPV A A92 N95 R257 N267 Q359 A363 I372 H376 A80 N83 R245 N255 Q347 A351 I360 H364
Gene Ontology
Molecular Function
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0015936 coenzyme A metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7m3h, PDBe:7m3h, PDBj:7m3h
PDBsum7m3h
PubMed
UniProtA0A4U3MLJ4

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