Structure of PDB 7m09 Chain A

Receptor sequence

>7m09A (length=331) Species: 9606 (Homo sapiens)

LDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINA
LKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVL
ELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLE
RMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHP
DGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRR
HRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTA
VVPGRVLPTPTEKDVFRLLGLPYREPAERDW

3D structure

• PDB: 7m09 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining.
• Chain: A
• Resolution: 1.65 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.
  4.2.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	W274 R514 R517 K521	W39 R279 R282 K286
BS02	dna	A	W342 G343 A344 G345 K347 T348 L474 D490 Y505	W107 G108 A109 G110 K112 T113 L239 D255 Y270
BS03	dna	A	Y267 W274 R275 Y279 P303 G304 G306 M309 K312	Y32 W39 R40 Y44 P68 G69 G71 M74 K77
BS04	dna	A	Q471 K472 R517 L527 E529 H530	Q236 K237 R282 L292 E294 H295
BS05	DUP	A	R386 G416 S417 R420 G426 D427 D429 Y505 T507 G508 A510 N513	R151 G181 S182 R185 G191 D192 D194 Y270 T272 G273 A275 N278
BS06	CA	A	D427 D429 D490	D192 D194 D255
BS07	MG	A	D427 D429 D490	D192 D194 D255
BS08	MG	A	D427 D429	D192 D194

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0034061 DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:7m09, PDBe:7m09, PDBj:7m09
• PDBsum: 7m09
• PubMed: 35778389
• UniProt: Q9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)