Structure of PDB 7m08 Chain A

Receptor sequence

>7m08A (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]

WVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKS
FHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELF
SNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMP
REEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGR
SHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRR
LDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAGRV
LPTPTEKDVFRLLGLPYREPAERDW

3D structure

PDB

7m08 Comprehensive structural survey of DNA double-strand break synapsis by DNA Polymerase Lambda

Chain

Resolution

1.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	W274 V462 S463 Q464 Q471 K472 R514 R517 L527 S528 H530	W36 V224 S225 Q226 Q233 K234 R276 R279 L289 S290 H292
BS02	dna	A	W342 G343 G345 K347 T348 D427 D429 R488 D490 Y505 F506 T507 G508 A510 N513	W104 G105 G107 K109 T110 D189 D191 R250 D252 Y267 F268 T269 G270 A272 N275
BS03	dna	A	W274 R275 Y279 P303 G304 G306 M309 K312	W36 R37 Y41 P65 G66 G68 M71 K74
BS04	MG	A	D427 D429 D490	D189 D191 D252

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7m08, PDBe:7m08, PDBj:7m08
PDBsum	7m08
PubMed
UniProt	Q9UGP5\|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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