Structure of PDB 7lxd Chain A

Receptor sequence
>7lxdA (length=1190) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DYFRIQLNNQDYYMSKPTFLDPSHESLPLNQFSQVPNIRVFGALPTGHQV
LCHVHGILPYMFIKYDGQITDTSTLRHQRCAQVHKTLEVKIRASFKKLGN
LNFVADVSVVKGIPFYGYHVGWNLFYKISLLNPSCLSRISELIRDGKIFG
KKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYFRSPVLNSILDIDKLT
INDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKLQH
RDIHHDFLEKREELSLKEYKETKRHVSGHQWQSSGEFEAFYKKAQHKTST
FDGQIPNFENFIDKNQKFSAINTPYEALPQLWPRLPQIEINNGKRAFVYG
EPPFGYQDILNKLEDEGFPKIDYKDPFFSNPVDLENKPYAYAGKRFEISS
THVSTRIPVQFGGETVSVYNKPTFDMFSSWKYALKPPTYDAVQKWYNKVP
SSSVHDSLTHLTLEIHANTRSDKIPDPAIDEVSMIIWCLEEETFPLDLDI
AYEGIMIVHKASEDSTFPTKIQHCINEIPVMFYESEFEMFEALTDLVLLL
DPDILSGFEIHNFSWGYIIERCQKIHQFDIVRELARVKCQISGIMITGRH
MINIWRALRSDVNLTQYTIESAAFNILHKRLPHFSFESLTNMWNAKKSTT
ELKTVLNYWLSRAQINIQLLRKQDYIARNIEQARLIGIDFHSVYYRGSQF
KVESFLIRICKSESFILLSPGKKDVRKQKALECVPLVMEPESAFYKSPLI
VLDFQSLYPSIMIGYNYCYSTMIGRVREINLTENNLGVSKFSLPRNILAL
LKNDVTIAPNGVVYAKTSVRKSTLSKMLTDILDVRVMIKKTMNEIGDDNT
TLKRLLNNKQLALKLLANVTYGYTSASFSGRMPCSDLADSIVQTGRETLE
KAIDIIEKDETWNAKVVYGDTDSLFVYLPGKTAIEAFSIGHAMAERVTQN
NPKPIFLKFEKVYHPSILISKKRYVGFSYESPSQTLPIFDAKGIETRDGI
PAQQKIIEKCIRLLFQTKDLSKIKKYLQNEFFKIQIGKVSAQDFCFAKEV
KPQYKERIPYLVVKGKQGQLLRERCVSPEEFLEGENLELDSEYYINKILI
PPLDRLFNLIGINVGNWAQEIVKSTTTLSFLIKKLKRQKEYQTLKTVCRT
CSYRYTSDAGIENDHIASKCNSYDCPVFYSRVKAERYLRD
3D structure
PDB7lxd Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
ChainA
Resolution4.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A R852 P854 V1445 C1446 C1449 C1468 C1473 V1475 F1476 R630 P632 V1147 C1148 C1151 C1170 C1175 V1177 F1178
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0019985 translesion synthesis
GO:0042276 error-prone translesion synthesis
GO:0070987 error-free translesion synthesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016035 zeta DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lxd, PDBe:7lxd, PDBj:7lxd
PDBsum7lxd
PubMed34174285
UniProtP14284|DPOZ_YEAST DNA polymerase zeta catalytic subunit (Gene Name=REV3)

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