Structure of PDB 7lwd Chain A

Receptor sequence
>7lwdA (length=541) Species: 9606 (Homo sapiens) [Search protein sequence]
GERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAI
FGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYY
NTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTS
PAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKT
SGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVW
IDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSG
FVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAII
FFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFG
SLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVK
EMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSII
LGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP
3D structure
PDB7lwd The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
ChainA
Resolution3.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IXX A Y95 D98 I172 F341 S438 G442 Y19 D22 I96 F265 S362 G366 BindingDB: IC50=8.8nM,Ki=20nM
BS02 YG7 A G100 R104 F335 E494 T497 P499 F556 S559 Y579 G24 R28 F259 E418 T421 P423 F480 S483 Y503 BindingDB: IC50=0.400000nM,Ki=0.5nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7lwd, PDBe:7lwd, PDBj:7lwd
PDBsum7lwd
PubMed34417466
UniProtP31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)

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